53755-02-5
53755-02-5
Chemical Structure
Clovamide
Synonym(s): trans-Clovamide
- CAS No.: 53755-02-5
- Formula:C18H17NO7
- Molecular Weight:359.33
IUPAC Name: (S,E)-3-(3,4-dihydroxyphenyl)-2-(3-(3,4-dihydroxyphenyl)acrylamido)propanoic acid
InChIKey: GPZFXSWMDFBRGS-UXONFWTHSA-N
SMILES: OC1=CC=C(C=C1O)/C=C/C(N[C@@H](CC2=CC=C(C(O)=C2)O)C(O)=O)=O
Biological Activity: Clovamide (trans-Clovamide), a natural phenolic compound, is a potent antioxidant. Clovamide is an excellent ROS and oxygen radical scavenger. Clovamide also has anti-inflammatory and neuroprotective effects[1][2]. Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, Trypanosoma evansi, and Heliobacter pylori[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Clovamide | 98.09% | Clovamide (trans-Clovamide), a natural phenolic compound, is a potent antioxidant. Clovamide is an excellent ROS and oxygen radical scavenger. Clovamide also has anti-inflammatory and neuroprotective effects. Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, Trypanosoma evansi, and Heliobacter pylori. | ||||||||||||||||||||
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cis-Clovamide | cis-Clovamide, a natural phenolic compound with antioxidant, anti-inflammatory and antiapoptotic activities. | |||||||||||||||||||||
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PI3K/Akt/CREB activator 1 | 98.64% | PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. PI3K/Akt/CREB activator 1 can be used in research of vascular dementia (VaD). | ||||||||||||||||||||
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Caffeoyltryptophan | 98.42% | Caffeoyltryptophan is a competitive PTP1B inhibitor, with an IC50 of 16.99 μM. Caffeoyltryptophan can also inhibit α-glucosidase, linoleic acid peroxidation and haemolysis. Caffeoyltryptophan can be used for the research of type 2 diabetes. | ||||||||||||||||||||
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(E/Z)-Scotanamine D | (E/Z)-Scotanamine D is a hydroxycinnamic acid amide found in the roots of Scopolia tangutica. (E/Z)-Scotanamine D is inactive against μ-, δ-, and κ-opioid receptors. | |||||||||||||||||||||
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N-trans-caffeoyloctopamine | N-trans-caffeoyloctopamine is a natural product. | |||||||||||||||||||||
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N-trans-Caffeoyltyramine | 99.72% | N-TRANS-CaffeoyLtyramine is an effective inflammatory response regulator, which has antioxidant activity and anticoagulation effects. | ||||||||||||||||||||
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N-(E)-Caffeoyldopamine | N-(E)-Caffeoyldopamine is an inhibitor of α-glucosidase that can be purified from Clerodendranthus Spicatus. N-(E)-Caffeoyldopamine shows a 53.73% inhibitory activity againstα-glucosidase. N-(E)-Caffeoyldopamine can be studied in diabetes research. | |||||||||||||||||||||
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(-)-N-[3',4'-Dihydroxy-(E)-cinnamoyl]-L-tyrosine | (-)-N-[3',4'-Dihydroxy-(E)-cinnamoyl]-L-tyrosine (Caffeoyl-N-tyrosine) is an N-phenylpropenoylamino acid compound that can be isolated from cocoa beans. (-)-N-[3',4'-Dihydroxy-(E)-cinnamoyl]-L-tyrosine is involved in cocoa flavor formation. | |||||||||||||||||||||
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N-trans-p-Coumaroyltyrosine | N-trans-p-Coumaroyltyrosine is a Alkaloids product that can be isolated from the herbs of Exochorda racemosa.. | |||||||||||||||||||||
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(+)-N-[3',4'-Dihydroxy-(E)-cinnamoyl]-L-aspartic acid | (+)-N-[3',4'-Dihydroxy-(E)-cinnamoyl]-L-aspartic acid is an N-phenylpropenoyl amino acid compound that can be isolated from cocoa beans. | |||||||||||||||||||||
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References
- [1]. Naike Ye, et al. Antioxidant studies by hydrodynamic voltammetry and DFT, quantitative analyses by HPLC-DAD of clovamide, a natural phenolic compound found in Theobroma Cacao L. beans. Food Chem. 2021 Mar 30;341(Pt 2):128260. [Content Brief]
- [2]. S Fallarini, et al. Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. Br J Pharmacol. 2009 Jul;157(6):1072-84. [Content Brief]
