53786-28-0
53786-28-0
Chemical Structure
R 29676
- CAS No.: 53786-28-0
- Formula:C12H14ClN3O
- Molecular Weight:251.72
IUPAC Name: 5-chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazol-2-ol
InChIKey: DOAYWDKFDPSTSV-UHFFFAOYSA-N
SMILES: C1=CC2=C(C=C1Cl)N=C(N2C3CCNCC3)O
Biological Activity: R 29676 is a putative metabolite of Halopemide (HY-119093). R 29676 inhibits the binding of sodium-independent GABA to postsynaptic GABA receptors. R 29676 inhibits the binding of benzodiazepines to rat forebrain membranes. R 29676 inhibits sodium-dependent GABA binding to transporters and uptake, as well as Serotonin (HY-B1473A) uptake by rat platelets[1][2].
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R 29676 | 99.80% | R 29676 is a putative metabolite of Halopemide (HY-119093). R 29676 inhibits the binding of sodium-independent GABA to postsynaptic GABA receptors. R 29676 inhibits the binding of benzodiazepines to rat forebrain membranes. R 29676 inhibits sodium-dependent GABA binding to transporters and uptake, as well as Serotonin (HY-B1473A) uptake by rat platelets. | ||||||||||||||||||||
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R 29676 (Standard) | ≥98% | R 29676 (Standard) is the analytical standard of R 29676 (HY-W103105). This product is intended for research and analytical applications. R 29676 is a putative metabolite of Halopemide (HY-119093). R 29676 inhibits the binding of sodium-independent GABA to postsynaptic GABA receptors. R 29676 inhibits the binding of benzodiazepines to rat forebrain membranes. R 29676 inhibits sodium-dependent GABA binding to transporters and uptake, as well as Serotonin (HY-B1473A) uptake by rat platelets. | ||||||||||||||||||||
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References
- [1]. Loonen A J M, et al. Halopemide, a new psychotropic agent: Cerebral distribution and receptor interactions[J]. Pharmaceutisch Weekblad, 1985, 7(1): 1-9.
- [2]. Loonen A J M, et al. Effects of halopemide on GABA receptor binding, uptake and release[J]. Brain Research, 1981, 210(1-2): 485-492. [Content Brief]
