53873-21-5
Chemical Structure
AGN-2979
Synonym(s): SC 48274; BTG 1501
- CAS No.: 53873-21-5
- Formula:C19H28N2O3
- Molecular Weight:332.44
IUPAC Name: ethyl (E)-2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate
InChIKey: UJFNSGBGJMRZKS-UHFFFAOYSA-N
SMILES: O=C1NC(C(CCCN(C)C)(C(C)(C1)C)C2=CC(OC)=CC=C2)=O
Biological Activity: AGN‑2979 (SC 48274; BTG 1501) is an orally active and selective tryptophan hydroxylase inhibitor with antidepressant-like and anxiolytic-like activities. AGN‑2979 inhibits stress-induced activation of tryptophan hydroxylase, thereby limiting the biosynthesis of 5-hydroxytryptamine in the brain. AGN-2979 possesses non-sedative anxiolytic and cognitive-enhancing properties. AGN-2979 is applicable to research related to depression and generalized anxiety disorder[1].
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AGN-2979 | AGN‑2979 (SC 48274; BTG 1501) is an orally active and selective tryptophan hydroxylase inhibitor with antidepressant-like and anxiolytic-like activities. AGN‑2979 inhibits stress-induced activation of tryptophan hydroxylase, thereby limiting the biosynthesis of 5-hydroxytryptamine in the brain. AGN-2979 possesses non-sedative anxiolytic and cognitive-enhancing properties. AGN-2979 is applicable to research related to depression and generalized anxiety disorder. | |||||||||||||||||||||
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References
- [1]. Gittos MW, et al. Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2001 Oct;11(5):351-7. [Content Brief]
