53912-89-3
53912-89-3
Chemical Structure
Anabasine hydrochloride
Synonym(s): (S)-Anabasine hydrochloride; (+)-Anabasine hydrochloride
- CAS No.: 53912-89-3
- Formula:C10H15ClN2
- Molecular Weight:198.69
IUPAC Name: (S)-3-(piperidin-2-yl)pyridine hydrochloride
InChIKey: VTMZQNZVYCJLGG-PPHPATTJSA-N
SMILES: [H]Cl.C1([C@H]2NCCCC2)=CC=CN=C1
Biological Activity: Anabasine ((S)-Anabasine) hydrochloride is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 µM)[1][2].
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Anabasine hydrochloride | Anabasine ((S)-Anabasine) hydrochloride is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 µM). | |||||||||||||||||||||
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References
- [1]. Green BT, et, al. Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors. Neurotoxicol Teratol. May-Jun 2010; 32(3): 383-90. [Content Brief]
- [2]. Palmer-Young EC, et, al. Context-dependent medicinal effects of anabasine and infection-dependent toxicity in bumble bees. PLoS One. 2017 Aug 23; 12(8): e0183729. [Content Brief]
