54-84-2
Chemical Structure
Cinanserin hydrochloride
Synonym(s): SQ 10643
- CAS No.: 54-84-2
- Formula:C20H25ClN2OS
- Molecular Weight:376.94
IUPAC Name: N-(2-((3-(dimethylamino)propyl)thio)phenyl)cinnamamide hydrochloride
InChIKey: LXGJPDKYMJJWRB-IERUDJENSA-N
SMILES: O=C(NC1=CC=CC=C1SCCCN(C)C)/C=C/C2=CC=CC=C2.[H]Cl
Biological Activity: Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro[1][2][3].
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Cinanserin hydrochloride | 99.48% | Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. | ||||||||||||||||||||
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Cinanserin hydrochloride (Standard) | ≥98% | Cinanserin (hydrochloride) (Standard) is the analytical standard of Cinanserin (hydrochloride) (HY-100943). This product is intended for research and analytical applications. Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. | ||||||||||||||||||||
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References
- [1]. Chen L, et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol. 2005 Jun;79(11):7095-103. [Content Brief]
- [2]. Hernekamp JF, et al. Cinanserin reduces plasma extravasation after burn plasma transfer in rats. Burns. 2013 Sep;39(6):1226-33. [Content Brief]
- [3]. Leysen JE, et al. Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. Life Sci. 1981 Mar 2;28(9):1015-22. [Content Brief]
