540733-03-7
Chemical Structure
JTP-59557
- CAS No.: 540733-03-7
- Formula:C18H15Cl2F3N4OS
- Molecular Weight:463.30
IUPAC Name: 4-(2-(tert-butyl)-4,5-dichlorophenyl)-5-((5-(trifluoromethyl)pyridin-2-yl)thio)-2,4-dihydro-3H-1,2,4-triazol-3-one
InChIKey: AKILCIXCGXREKT-UHFFFAOYSA-N
SMILES: O=C1NN=C(SC2=NC=C(C=C2)C(F)(F)F)N1C3=CC(Cl)=C(Cl)C=C3C(C)(C)C
Biological Activity: JTP-59557 is an orally active, stereospecific noncompetitive inhibitor of type IIb sodium/phosphate cotransporter (NaPi-IIb). JTP-59557 selectively inhibits type IIb-mediated inorganic phosphate uptake, without affecting Na+-independent inorganic phosphate transport or Na+-dependent D-glucose (HY-B0389) transport. JTP-59557 also suppresses Na+-dependent inorganic phosphate transport in intestinal brush border membrane vesicles. JTP-59557 is applicable to research related to hyperphosphatemia and hyperphosphatemia associated with chronic kidney disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JTP-59557 | JTP-59557 is an orally active, stereospecific noncompetitive inhibitor of type IIb sodium/phosphate cotransporter (NaPi-IIb). JTP-59557 selectively inhibits type IIb-mediated inorganic phosphate uptake, without affecting Na+-independent inorganic phosphate transport or Na+-dependent D-glucose (HY-B0389) transport. JTP-59557 also suppresses Na+-dependent inorganic phosphate transport in intestinal brush border membrane vesicles. JTP-59557 is applicable to research related to hyperphosphatemia and hyperphosphatemia associated with chronic kidney disease. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Matsuo A, et al. Inhibitory effect of JTP-59557, a new triazole derivative, on intestinal phosphate transport in vitro and in vivo. European journal of pharmacology. 2005 Jul 04;517(1-2):111-9. [Content Brief]
- [2]. Miyamoto K, et al. Sodium-dependent phosphate cotransporters: lessons from gene knockout and mutation studies. Journal of pharmaceutical sciences. 2011 Sep;100(9):3719-30. [Content Brief]
