5428-80-8
5428-80-8
Chemical Structure
Vacquinol-1
Synonym(s): NSC13316
- CAS No.: 5428-80-8
- Formula:C21H21ClN2O
- Molecular Weight:352.86
IUPAC Name: (2-(4-chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol
InChIKey: VKLJPGAHSLIQKH-UHFFFAOYSA-N
SMILES: OC(C1NCCCC1)C2=CC(C3=CC=C(Cl)C=C3)=NC4=CC=CC=C24
Biological Activity: Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates the MAPK pathway. Vacquinol-1 inhibits the growth, migration and colony formation, and induces apoptosis of cancer cells. Vacquinol-1 is applicable to research related to cancers such as hepatocellular carcinoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Vacquinol-1 | 99.33% | Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates the MAPK pathway. Vacquinol-1 inhibits the growth, migration and colony formation, and induces apoptosis of cancer cells. Vacquinol-1 is applicable to research related to cancers such as hepatocellular carcinoma. | ||||||||||||||||||||
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References
- [1]. Sun SL, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563. [Content Brief]
- [2]. Wu C, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019;239:116881. [Content Brief]
