544678-85-5
544678-85-5
Chemical Structure
DB04760
- CAS No.: 544678-85-5
- Formula:C22H20F2N4O2
- Molecular Weight:410.42
IUPAC Name: N4,N6-bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide
InChIKey: PYFRREJCFXFNRR-UHFFFAOYSA-N
SMILES: FC1=C(C=C(C=C1)CNC(C2=CC(C(NCC3=CC=C(C(C)=C3)F)=O)=NC=N2)=O)C
Biological Activity: DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM[1]. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DB04760 | 99.18% | DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity. | ||||||||||||||||||||
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References
- [1]. Engel CK, et al. Structural basis for the highly selective inhibition of MMP-13. Chem Biol. 2005 Feb;12(2):181-9. [Content Brief]
- [2]. Thomas S. Lisse, et al. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15): E2189–E2198. [Content Brief]
