544681-96-1
544681-96-1
Chemical Structure
GATA4-NKX2-5-IN-1
- CAS No.: 544681-96-1
- Formula:C21H23N3O2
- Molecular Weight:349.43
IUPAC Name: N-(4-(diethylamino)phenyl)-5-methyl-3-phenylisoxazole-4-carboxamide
InChIKey: UDDOZWWBHVIGDS-UHFFFAOYSA-N
SMILES: CC1=C(C(NC2=CC=C(N(CC)CC)C=C2)=O)C(C3=CC=CC=C3)=NO1
Biological Activity: GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GATA4-NKX2-5-IN-1 | 99.24% | GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression. | ||||||||||||||||||||
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GATA4-NKX2-5-IN-1 (Standard) | ≥98% | GATA4-NKX2-5-IN-1 (Standard) is the analytical standard of GATA4-NKX2-5-IN-1 (HY-103484). This product is intended for research and analytical applications. GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression. | ||||||||||||||||||||
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