5451-40-1
5451-40-1
Chemical Structure
2,6-Dichloropurine
- CAS No.: 5451-40-1
- Formula:C5H2Cl2N4
- Molecular Weight:189.00
IUPAC Name: 2,6-dichloro-3H-purine
InChIKey: RMFWVOLULURGJI-UHFFFAOYSA-N
SMILES: C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2
Biological Activity: 2,6-Dichloropurine is a purine derivative, PDE inhibitor analog, and synthetic intermediate for N7-glycosylated purine nucleosides, nucleosides and nucleotides. 2,6-Dichloropurine is applicable to cancer-related research[1][2][3].
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2,6-Dichloropurine | 98.91% | 2,6-Dichloropurine is a purine derivative, PDE inhibitor analog, and synthetic intermediate for N7-glycosylated purine nucleosides, nucleosides and nucleotides. 2,6-Dichloropurine is applicable to cancer-related research. | ||||||||||||||||||||
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AHL-Pu-2 | AHL-Pu-2 is the clickable electrophilic purine. AHL-Pu-2 can be used to directly quantify protein-RNA interactions on proteins through photoaffinity competition with 4-thiouridine (4SU)-labeled RNA in cells. | |||||||||||||||||||||
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2,4-Dichlorothieno[3,2-d]pyrimidine | 2,4-Dichlorothieno[3,2-d]pyrimidine is a thienopyrimidine scaffold and a key synthetic precursor, which is widely used for constructing 4-arylthieno[3,2-d]pyrimidine compounds. 2,4-Dichlorothieno[3,2-d]pyrimidine serves for the development of 4-arylthieno[3,2-d]pyrimidine-based human adenosine A2a receptor antagonists, as well as thienopyrimidine-based PI3K-α inhibitors. In addition, 2,4-Dichlorothieno[3,2-d]pyrimidine has potential application value in studies related to whipworm disease. | |||||||||||||||||||||
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2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine | 99.97% | 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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6-Chloro-2-fluoro-9H-purine | 6-Chloro-2-fluoro-9H-purine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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2-Fluoroadenine | 99.68% | 2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer. | ||||||||||||||||||||
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7H-Purine-2,6-diamine | 99.99% | 7H-Purine-2,6-diamine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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2-Chloroadenine | 99.48% | 2-Chloroadenine (6-Amino-2-chloropurine) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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5,7-Dichlorothiazolo[5,4-d]pyrimidine | 99.90% | 5,7-Dichlorothiazolo[5,4-d]pyrimidine (5,7-dichloro-[1,3]thiazolo[5,4-d]pyriMidine) is a building block in the chemical synthesis. | ||||||||||||||||||||
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6-Chloropurine | 99.47% | 6-Chloropurine is a building block in chemical synthesis. Intermediate in the preparation of 9-alkylpurines and 6-rnercaptopurine. Antitumor activities. | ||||||||||||||||||||
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2-Amino-6-chloropurine | 99.79% | 6-Chloroguanine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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References
- [1]. Kozai S, et al. Synthesis and biological activity of 9-(2, 6-difluorobenzyl)-9H-purines bearing chlorine[J]. Chemical and pharmaceutical bulletin, 1999, 47(4): 574-575.
- [2]. Tranová L, et al. Study of the Regioselective Glycosylation of 6-Chloropurine and 2,6-Dichloropurine with Tin and Titanium Tetrachloride. The Journal of organic chemistry. 2021 Oct 01;86(19):13265-13275.
- [3]. Guna K, et al. Structural, spectroscopic, electronic, Hirshfeld, QTAIM and biological predications of a hybrid 2, 6-dichloropurine compound: A detailed density functional theoretical study[J]. Journal of the Indian Chemical Society, 2023, 100(5): 100984.
