54680-12-5
Chemical Structure
2'-Deoxyadenosine-5'-triphosphate trisodium
Synonym(s): dATP trisodium
- CAS No.: 54680-12-5
- Formula:C10H13N5Na3O12P3
- Molecular Weight:557.13
IUPAC Name: sodium ((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate
InChIKey: VEESQMCFNINIMU-PWDLANNDSA-K
SMILES: O[C@H]([C@H](O1)CO[P](O[P](O[P](O)(O[Na])=O)(O[Na])=O)(O[Na])=O)C[C@@H]1N2C3=NC=NC(N)=C3N=C2
Biological Activity: 2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency [1][2][3][4].
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2'-Deoxyadenosine-5'-triphosphate trisodium | 98.0% | 2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency . | ||||||||||||||||||||
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2'-Deoxyadenosine-5'-triphosphate trisodium (Standard) | ≥98% | 2'-Deoxyadenosine-5'-triphosphate trisodium (Standard) (dATP trisodium (Standard)) is the analytical standard of 2'-Deoxyadenosine-5'-triphosphate trisodium (HY-136648A). This product is intended for research and analytical applications. 2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. | ||||||||||||||||||||
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2'-Deoxyadenosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade | 99.0% | 2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium, 100 mM Solution, PCR Gradeis one of the raw materials used by DNA polymerase to synthesize long DNA strands during DNA replication. 2'-Deoxyadenosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade is used in reverse transcription polymerase chain reaction (RT-PCR) for DNA amplification. This product is supplied in the form of an aqueous solution. |
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References
- [1]. P J Romaniuk, A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. J Biol Chem. 1982 Jul 10;257(13):7684-8. [Content Brief]
- [2]. Yang JC, Cortopassi GA. dATP causes specific release of cytochrome C from mitochondria. Biochem Biophys Res Commun. 1998 Sep 18;250(2):454-7. [Content Brief]
- [3]. Katona K, et al. Deoxy-adenosine-monophosphate (dAMP) di-n-butylester induces apoptosis by increasing the dATP level in HL-60 cells. Cancer Lett. 2006 Apr 28;235(2):281-90. [Content Brief]
- [4]. Xi C, Wu J. dATP/ATP, a multifunctional nucleotide, stimulates bacterial cell lysis, extracellular DNA release and biofilm development. PLoS One. 2010 Oct 14;5(10):e13355. [Content Brief]
