5489-57-6
5489-57-6
Chemical Structure
Arborinine
- CAS No.: 5489-57-6
- Formula:C16H15NO4
- Molecular Weight:285.29
IUPAC Name: 1-hydroxy-2,3-dimethoxy-10-methylacridin-9(10H)-one
InChIKey: ATBZZQPALSPNMF-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=CC=C2)N(C)C3=CC(OC)=C(OC)C(O)=C13
Biological Activity: Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Arborinine | 99.87% | Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity . | ||||||||||||||||||||
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References
- [1]. Feng C, et al. Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling. Food Nutr Res. 2022 Sep 16;66. [Content Brief]
- [2]. Chu Y, et al. Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells. Invest New Drugs. 2021 Jun;39(3):627-635. [Content Brief]
