55-57-2
55-57-2
Chemical Structure
Phenylbiguanide hydrochloride
Synonym(s): N-Phenylbiguanide hydrochloride; PBG hydrochloride; 1-Phenylbiguanide hydrochloride
- CAS No.: 55-57-2
- Formula:C8H12ClN5
- Molecular Weight:213.67
InChIKey: FHUDRDSKZQDCBC-UHFFFAOYSA-N
SMILES: NC(NC(NC1=CC=CC=C1)=N)=N.Cl
Biological Activity: Phenylbiguanide hydrochloride is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phenylbiguanide hydrochloride | 99.96% | Phenylbiguanide hydrochloride is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM. | ||||||||||||||||||||
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m-CPBG hydrochloride | 99.85% | m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease. | ||||||||||||||||||||
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4-Chlorophenylguanidine hydrochloride | 99.07% | 4-Chlorophenylguanidine hydrochloride is an urokinase-type plasminogen activator inhibitor. 4-Chlorophenylguanidine hydrochloride is a potent ASIC3 positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo. | ||||||||||||||||||||
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Phenylbiguanide | 98.0% | Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM. | ||||||||||||||||||||
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m-Chlorophenylbiguanide | m-Chlorophenylbiguanide (mCPBG) is a potent high-affinity agonist of the 5-HT3 receptor, exhibiting an inhibitory effect on long-term potentiation (LTP) in the mossy fiber-CA3 system. mCPBG attenuates the magnitude of LTP at concentrations of 0.3-1 microM, demonstrating its role in modulating synaptic plasticity. Additionally, the impact of mCPBG on LTP is reversible by the GABAA receptor antagonist bicuculline, indicating a connection between its action and GABAergic neurotransmission. | |||||||||||||||||||||
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Phenformin | 98.02% | Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin inhibits cancer stem cells (CSCs) and possesses potent antitumor potential. | ||||||||||||||||||||
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1-Phenylurea | 99.85% | 1-Phenylurea (Phenylurea) is a kind of biological materials or organic compounds that are widely used in life science research. | ||||||||||||||||||||
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Defenuron | Defenuron (IPO 4328) is a herbicide for controlling undesirable grasses and broad-leaved plants in a variety of crops. | |||||||||||||||||||||
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1-Phenylsemicarbazide | 97.0% | 1-Phenylsemicarbazide is an antifungal agent. 1-Phenylsemicarbazide has the potential for preventing mold growth on industrial products. | ||||||||||||||||||||
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Phenylthiourea | 99.26% | Phenylthiourea (Phenylthiocarbamide) is an inhibitor for phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki = 0.21 μM). Phenylthiourea is an effective inhibitor for tyrosinase. Phenylthiourea can lead to graying of hair in black rats due to the interference with melanin formation. | ||||||||||||||||||||
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