552332-71-5
552332-71-5
Chemical Structure
DB07107
- CAS No.: 552332-71-5
- Formula:C23H22N4O
- Molecular Weight:370.45
IUPAC Name: (R,E)-1-(1H-indol-3-yl)-3-((5-(2-(pyridin-4-yl)vinyl)pyridin-3-yl)oxy)propan-2-amine
InChIKey: SGHXFHRRWFLILP-RRFGBZISSA-N
SMILES: N[C@@H](COC1=CN=CC(/C=C/C2=CC=NC=C2)=C1)CC3=CNC4=C3C=CC=C4
Biological Activity: DB07107 is a potent agent resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM[1][2].
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DB07107 | DB07107 is a potent agent resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM. | |||||||||||||||||||||
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References
- [1]. Banavath HN, et al. Identification of novel tyrosine kinase inhibitors for drug resistant T315I mutant BCR-ABL: a virtual screening and molecular dynamics simulations study. Sci Rep. 2014 Nov 10;4:6948. [Content Brief]
- [2]. Li Q, et al. Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1679-85. [Content Brief]
