55300-30-6
Chemical Structure
Antrafenine dihydrochloride
Synonym(s): Stakane dihydrochloride
- CAS No.: 55300-30-6
- Formula:C30H28Cl2F6N4O2
- Molecular Weight:661.47
IUPAC Name: 2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl 2-((7-(trifluoromethyl)quinolin-4-yl)amino)benzoate dihydrochloride
InChIKey: GEZLWXYIFNEJBC-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1NC2=C3C=CC(C(F)(F)F)=CC3=NC=C2)OCCN4CCN(C5=CC=CC(C(F)(F)F)=C5)CC4.Cl.Cl
Biological Activity: Antrafenine (Stakane) dihydrochloride is a non-narcotic analgesic. Antrafenine dihydrochloride demonstrates central analgesic effects in acetic acid writhing test and mouse hot plate test experiments. Antrafenine dihydrochloride significantly alleviates osteoarthritis pain. Antrafenine dihydrochloride exhibits mild anti-inflammatory activity in a rat toe edema model. Antrafenine dihydrochloride can be used for pain and anti-inflammatory research[1][2].
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Antrafenine dihydrochloride | Antrafenine (Stakane) dihydrochloride is a non-narcotic analgesic. Antrafenine dihydrochloride demonstrates central analgesic effects in acetic acid writhing test and mouse hot plate test experiments. Antrafenine dihydrochloride significantly alleviates osteoarthritis pain. Antrafenine dihydrochloride exhibits mild anti-inflammatory activity in a rat toe edema model. Antrafenine dihydrochloride can be used for pain and anti-inflammatory research. | |||||||||||||||||||||
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References
- [1]. Manoury PM, et al. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. J Med Chem. 1979;22(5):554-559. [Content Brief]
- [2]. Berry H, et al. Antrafenine, naproxen and placebo in osteoarthritis: a comparative study. Br J Rheumatol. 1983 May;22(2):89-94. [Content Brief]
