55308-64-0
55308-64-0
Chemical Structure
L11204
Synonym(s): DL-204-IT
- CAS No.: 55308-64-0
- Formula:C18H17N3O
- Molecular Weight:291.35
IUPAC Name: 2-(3-ethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[5,1-a]isoquinoline
InChIKey: NZDDMKIDRQAGND-UHFFFAOYSA-N
SMILES: CCOC1=CC(C2=NN(CCC3=C4C=CC=C3)C4=N2)=CC=C1
Biological Activity: L11204 (DL-204-IT) is a potent inhibitor of prostaglandin metabolism. L11204 inhibits PMS-induced superovulation and reduced the number of recoverable ova in the oviducts of hamsters. L11204 also inhibits chorionic gonadotrophin-induced ovarian hypertrophy and steroidogenesi in rats. L11204 is promising for research of reproductive system disorders[1][2].
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L11204 | L11204 (DL-204-IT) is a potent inhibitor of prostaglandin metabolism. L11204 inhibits PMS-induced superovulation and reduced the number of recoverable ova in the oviducts of hamsters. L11204 also inhibits chorionic gonadotrophin-induced ovarian hypertrophy and steroidogenesi in rats. L11204 is promising for research of reproductive system disorders. | |||||||||||||||||||||
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References
- [1]. Valenzuela G, et al. Effect of inhibitors of prostaglandin synthesis and metabolism on ovum transport in the rabbit. Fertil Steril. 1977 Sep;28(9):992-7. [Content Brief]
- [2]. Lerner L J, et al. Inhibition of superovulation and alteration of ova transportation in hamsters by prostaglandin and DL-204-IT, an anti-fertility agent[J]. Prostaglandins and Medicine, 1981, 6(4): 369-374.
