554403-08-6
554403-08-6
Chemical Structure
WAY-181187 hydrochloride
Synonym(s): SAX-187 hydrochloride
- CAS No.: 554403-08-6
- Formula:C15H14Cl2N4O2S2
- Molecular Weight:417.33
IUPAC Name: 2-(1-((6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl)-1H-indol-3-yl)ethan-1-amine hydrochloride
InChIKey: YWNBHKWSECANPP-UHFFFAOYSA-N
SMILES: NCCC1=CN(S(=O)(C2=C(Cl)N=C3SC=CN32)=O)C4=C1C=CC=C4.[H]Cl
Biological Activity: WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].
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WAY-181187 hydrochloride | WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist. | |||||||||||||||||||||
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References
- [1]. Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. [Content Brief]
- [2]. Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14. [Content Brief]
