55673-89-7
Chemical Structure
1,2,3,4,7,8,9-Heptachlorodibenzofuran
Synonym(s): 1,2,3,4,7,8,9-HpCDF
- CAS No.: 55673-89-7
- Formula:C12HCl7O
- Molecular Weight:409.31
IUPAC Name: 1,2,3,4,7,8,9-heptachlorodibenzo[b,d]furan
InChIKey: VEZCTZWLJYWARH-UHFFFAOYSA-N
SMILES: C1=C2C(=C(C(=C1Cl)Cl)Cl)C3=C(O2)C(=C(C(=C3Cl)Cl)Cl)Cl
Biological Activity: 1,2,3,4,7,8,9-Heptachlorodibenzofuran (1,2,3,4,7,8,9-HpCDF) is a compound that induces the expression of CYP1A1 and CYP1B1 genes in human peripheral blood lymphocytes, while also promoting the expression of the aryl hydrocarbon receptor repressor (AhRR). 1,2,3,4,7,8,9-Heptachlorodibenzofuran can increase ethoxyresorufin-O-deethylase (EROD) activity in isolated human peripheral blood lymphocytes in a concentration-dependent manner, which serves as a marker of CYP1A1 activity. Furthermore, 1,2,3,4,7,8,9-Heptachlorodibenzofuran exhibits immunosuppressive effects by reducing the number of splenic plaque-forming cells in mice and increasing aryl hydrocarbon hydroxylase (AHH) activity in liver microsomes of mice injected with sheep red blood cells. 1,2,3,4,7,8,9-Heptachlorodibenzofuran can be used in research in the fields of immunology, metabolic diseases, and environmental toxicology[1][2][3][4].
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1,2,3,4,7,8,9-Heptachlorodibenzofuran | 1,2,3,4,7,8,9-Heptachlorodibenzofuran (1,2,3,4,7,8,9-HpCDF) is a compound that induces the expression of CYP1A1 and CYP1B1 genes in human peripheral blood lymphocytes, while also promoting the expression of the aryl hydrocarbon receptor repressor (AhRR). 1,2,3,4,7,8,9-Heptachlorodibenzofuran can increase ethoxyresorufin-O-deethylase (EROD) activity in isolated human peripheral blood lymphocytes in a concentration-dependent manner, which serves as a marker of CYP1A1 activity. Furthermore, 1,2,3,4,7,8,9-Heptachlorodibenzofuran exhibits immunosuppressive effects by reducing the number of splenic plaque-forming cells in mice and increasing aryl hydrocarbon hydroxylase (AHH) activity in liver microsomes of mice injected with sheep red blood cells. 1,2,3,4,7,8,9-Heptachlorodibenzofuran can be used in research in the fields of immunology, metabolic diseases, and environmental toxicology. | |||||||||||||||||||||
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1,2,3,4,7,8,9-Heptachlorodibenzofuran-13C12 | 1,2,3,4,7,8,9-Heptachlorodibenzofuran-13C12 is 13C labeled 1,2,3,4,7,8,9-Heptachlorodibenzofuran. | |||||||||||||||||||||
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References
- [1]. Dickerson R, et al. The structure-dependent effects of heptachlorodibenzofuran isomers in male C57BL/6 mice: immunotoxicity and monooxygenase enzyme induction. Fundam Appl Toxicol. 1990 Aug;15(2):298-307. [Content Brief]
- [2]. van Ede KI, et al. Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicol Lett. 2014 Apr 7;226(1):43-52. [Content Brief]
- [3]. Hu SW, et al. PCDD/Fs levels in indoor environments and blood of workers of three municipal waste incinerators in Taiwan. Chemosphere. 2004 Apr;55(4):611-20. [Content Brief]
- [4]. Tawara K, et al. Effects of maternal dioxin exposure on newborn size at birth among Japanese mother-infant pairs. Environ Health Prev Med. 2009 Mar;14(2):88-95. [Content Brief]
