5577-13-9
5577-13-9
Chemical Structure
Ethyl tosylcarbamate
- CAS No.: 5577-13-9
- Formula:C10H13NO4S
- Molecular Weight:243.28
IUPAC Name: ethyl tosylcarbamate
InChIKey: DFWQXANLGSXMKF-UHFFFAOYSA-N
SMILES: O=C(OCC)NS(=O)(C1=CC=C(C)C=C1)=O
Biological Activity: Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].
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Ethyl tosylcarbamate | 98.87% | Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877). Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. | ||||||||||||||||||||
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Ethyl tosylcarbamate-d7 | Ethyl tosylcarbamate-d7 is the deuterium labeled Ethyl tosylcarbamate (HY-135337). Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877). Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. | |||||||||||||||||||||
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References
- [1]. Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27(4):301-27. [Content Brief]
- [2]. Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57(13), 1476–1478.
- [3]. Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55(6): p. 722-30. [Content Brief]
