560111-91-3
560111-91-3
Chemical Structure
FK3453
- CAS No.: 560111-91-3
- Formula:C17H17N5O
- Molecular Weight:307.35
InChIKey: QECZSUGQZHURLI-UHFFFAOYSA-N
SMILES: O=C1C=CC(C2=C(C3=CC=CC=C3)N=C(N)N=C2)=NN1C(C)C
Biological Activity: FK3453 is a dual adenosine A1/A2 inhibitor and a TSLP inhibitor. FK3453 is also a substrate of aldehyde oxidase (AO). FK3453 can inhibit the production of TSLP and IL-33. FK3453 is useful for research on Parkinson’s disease and allergic disorders[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FK3453 | 99.98% | FK3453 is a dual adenosine A1/A2 inhibitor and a TSLP inhibitor. FK3453 is also a substrate of aldehyde oxidase (AO). FK3453 can inhibit the production of TSLP and IL-33. FK3453 is useful for research on Parkinson’s disease and allergic disorders. | ||||||||||||||||||||
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References
- [1]. Sanoh S, et al. Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes. Drug Metab Dispos. 2012;40(1):76-82. [Content Brief]
- [2]. Segawa R, et al. Inhibition of thymic stromal lymphopoietin production by FK3453. J Pharmacol Sci. 2022;149(4):198-204. [Content Brief]
- [3]. Akabane T, et al. Case report of extensive metabolism by aldehyde oxidase in humans: pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans. Xenobiotica. 2011;41(5):372-384. [Content Brief]
