56518-41-3
56518-41-3
Chemical Structure
Brodimoprim
Synonym(s): Ro 10-5970
- CAS No.: 56518-41-3
- Formula:C13H15BrN4O2
- Molecular Weight:339.19
IUPAC Name: 5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine-2,4-diamine
InChIKey: BFCRRLMMHNLSCP-UHFFFAOYSA-N
SMILES: COC1=C(C(OC)=CC(CC2=CN=C(N=C2N)N)=C1)Br
Biological Activity: Brodimoprim (Ro 10-5970), a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Brodimoprim | 99.36% | Brodimoprim (Ro 10-5970), a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria. | ||||||||||||||||||||
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Brodimoprim (Standard) | ≥98% | Brodimoprim (Standard) is the analytical standard of Brodimoprim. This product is intended for research and analytical applications. Brodimoprim (Ro 10-5970), a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria. | ||||||||||||||||||||
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Brodimoprim-d6 | Brodimoprim-d6 (Ro 10-5970-d6) is a deuterium labeled Brodimoprim. Brodimoprim, a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria. | |||||||||||||||||||||
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Metioprim | Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria. | |||||||||||||||||||||
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Aditoprime (Standard) | ≥98% | Aditoprime (Standard) is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR, respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics. | ||||||||||||||||||||
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N-Didesmethyladitoprim | N-Didesmethyladitoprim is a metabolite of Aditoprime (HY-139743). Aditoprime is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR , respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics. | |||||||||||||||||||||
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Trimethoprim | 99.97% | Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc. | ||||||||||||||||||||
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Trimethoprim hydrochloride | 99.16% | Trimethoprim hydrochloride is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim hydrochloride is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim hydrochloride has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim hydrochloride can inhibit infection of Influenza A virus in chick embryo when combinated with zinc. | ||||||||||||||||||||
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Trimethoprim-d3 | 98.12% | Trimethoprim-d3is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment. | ||||||||||||||||||||
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Trimethoprim-13C3 | Trimethoprim-13C3 is the deuterium labeled Trimethoprim (HY-B0510). Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc. | |||||||||||||||||||||
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Diaveridine | 99.69% | Diaveridine (EGIS-5645) is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent. | ||||||||||||||||||||
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4′-DTMP | 97.0% | 4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli. | ||||||||||||||||||||
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3',4'-Dihydroxytrimethoprim | 3',4'-Dihydroxytrimethoprim is a Trimethoprim (HY-B0510) derivative. 3',4'-Dihydroxytrimethoprim forms via sequential O-demethylation of Trimethoprim in human liver microsomes. 3',4'-Dihydroxytrimethoprim can be used for metabolic research. | |||||||||||||||||||||
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