568-01-4
Chemical Structure
Melicopine
- CAS No.: 568-01-4
- Formula:C17H15NO5
- Molecular Weight:313.30
IUPAC Name: 4,5-dimethoxy-11-methyl-[1,3]dioxolo[4,5-c]acridin-6(11H)-one
InChIKey: PEWWLIQAXYMMAN-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C)C3=C4OCOC4=C(C(OC)=C13)OC)C=CC=C2
Biological Activity: Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC50 values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC50 values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC50 greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields[1].
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Melicopine | Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC50 values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC50 values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC50 greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields. | |||||||||||||||||||||
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