57117-44-9
Chemical Structure
1,2,3,6,7,8-Hexachlorodibenzofuran
Synonym(s): 1,2,3,6,7,8-HxCDF
- CAS No.: 57117-44-9
- Formula:C12H2Cl6O
- Molecular Weight:374.86
InChIKey: JEYJJJXOFWNEHN-UHFFFAOYSA-N
SMILES: ClC1=C(Cl)C(Cl)=C(OC2=CC(Cl)=C(Cl)C(Cl)=C23)C3=C1
Biological Activity: 1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 1,2,3,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 1.47 and 1.24 nM, respectively). 1,2,3,6,7,8-Hexachlorodibenzofuran reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats (EC50s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively)[1][2][3].
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1,2,3,6,7,8-Hexachlorodibenzofuran | 1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 1,2,3,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 1.47 and 1.24 nM, respectively). 1,2,3,6,7,8-Hexachlorodibenzofuran reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats (EC50s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively). | |||||||||||||||||||||
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References
- [1]. Harnly M, et al. Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Contamination at Metal Recovery Facilities, Open Burn Sites, and a Railroad Car Incineration Facility. Environ Sci Technol. 1995 Mar 1;29(3):677-84. [Content Brief]
- [2]. Mason G, et al. Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-activity relationships. Toxicology. 1985 Oct;37(1-2):1-12. [Content Brief]
- [3]. Bandiera S, et al. Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology. 1984 Aug;32(2):131-44. [Content Brief]
