573-54-6
573-54-6
Chemical Structure
2-Bromo-3-nitrobenzoic acid
- CAS No.: 573-54-6
- Formula:C7H4BrNO4
- Molecular Weight:246.02
IUPAC Name: 2-bromo-3-nitrobenzoic acid
InChIKey: WTDJEGSXLFHZPY-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=CC([N+]([O-])=O)=C1Br
Biological Activity: 2-Bromo-3-nitrobenzoic acid is a brominated nitrobenzoic acid and also a starting material for the synthesis of 3-substituted-5-nitroisocoumarins. 3-Substituted-5-nitroisocoumarins are key intermediates of PARP inhibitor analogs. 2-Bromo-3-nitrobenzoic acid serves as an easily accessible precursor for the synthesis of 7-nitrobenzo[b]thiophene and 7-nitro-1,2-benzisothiazole derivatives[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-Bromo-3-nitrobenzoic acid | 98.81% | 2-Bromo-3-nitrobenzoic acid is a brominated nitrobenzoic acid and also a starting material for the synthesis of 3-substituted-5-nitroisocoumarins. 3-Substituted-5-nitroisocoumarins are key intermediates of PARP inhibitor analogs. 2-Bromo-3-nitrobenzoic acid serves as an easily accessible precursor for the synthesis of 7-nitrobenzo[b]thiophene and 7-nitro-1,2-benzisothiazole derivatives. | ||||||||||||||||||||
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References
- [1]. Woon EC, et al. One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs. Bioorganic & medicinal chemistry. 2013 Sep 01;21(17):5218-27.
- [2]. Rahman L K A, Scrowston R M. 7-Substituted benzo [b] thiophenes and 1, 2-benzisothiazoles. Part 2. Chloro and nitro derivatives[J]. Journal of the Chemical Society, Perkin Transactions 1, 1984, 13: 385-390.
