57495-14-4
57495-14-4
Chemical Structure
Ketoprofen sodium
Synonym(s): 19583 RP-Na
- CAS No.: 57495-14-4
- Formula:C16H13NaO3
- Molecular Weight:276.26
InChIKey: OAPDLBHLMVYMCW-UHFFFAOYSA-M
SMILES: O=C(C(C)C1=CC(C(C2=CC=CC=C2)=O)=CC=C1)O[Na]
Biological Activity: Ketoprofen (RP-19583) sodium is a non-steroidal anti-inflammatory agent. Ketoprofen sodium can inhibit the activity of Cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). Ketoprofen is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].
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Ketoprofen sodium | Ketoprofen (RP-19583) sodium is a non-steroidal anti-inflammatory agent. Ketoprofen sodium can inhibit the activity of Cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). Ketoprofen is potential in the research of inflammation, immunology, and metabolic disease such as obesity. | |||||||||||||||||||||
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References
- [1]. Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12(4):533-7. [Content Brief]
- [2]. NamHyeon Kang Ketoprofen alleviates diet-induced obesity and promotes white fat browning in mice via the activation of COX-2 through mTORC1-p38 signaling pathway. Pflugers Arch. 2020 May;472(5):583-596. [Content Brief]
- [3]. Denisa Dan, et al. Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro. J Dairy Sci. 2018 Dec;101(12):11321-11329. [Content Brief]
