576-44-3
576-44-3
Chemical Structure
Kanosamine
Synonym(s): 3-Amino-3-deoxyglucose
- CAS No.: 576-44-3
- Formula:C6H13NO5
- Molecular Weight:179.17
IUPAC Name: (2R,3S,4S,5R)-3-amino-2,4,5,6-tetrahydroxyhexanal
InChIKey: FOEXHEVNPRRHDY-SLPGGIOYSA-N
SMILES: O=C[C@H](O)[C@H]([C@H](O)[C@H](O)CO)N
Biological Activity: Kanosamine (3-Amino-3-deoxyglucose) is an antibiotic against Saccharomyces cerevisiae and human pathogenic fungi Candida albicans. Kanosamine exhibits antifungal activity through inhibition of cell wall synthesis and inhibition of GlcN-6-P synthase with phosphorylated kanosamine-6-phosphate in cytoplasma[1][2].
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Kanosamine | Kanosamine (3-Amino-3-deoxyglucose) is an antibiotic against Saccharomyces cerevisiae and human pathogenic fungi Candida albicans. Kanosamine exhibits antifungal activity through inhibition of cell wall synthesis and inhibition of GlcN-6-P synthase with phosphorylated kanosamine-6-phosphate in cytoplasma. | |||||||||||||||||||||
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References
- [1]. Janiak AM, et al., Mechanism of antifungal action of kanosamine. Med Mycol. 2001 Oct;39(5):401-8. [Content Brief]
- [2]. Iwai Y, Tet al., Studies on bacterial cell wall inhibitors. III. 3-amino-3-deoxy-D-glucose, an inhibitor of bacterial cell wall synthesis. Biochim Biophys Acta. 1977 Jun 23;498(1):223-8. [Content Brief]
