58053-83-1
Chemical Structure
17β-Hydroxywortmannin
Synonym(s): Wortmannin-17β-ol
- CAS No.: 58053-83-1
- Formula:C23H26O8
- Molecular Weight:430.45
IUPAC Name: (1S,6bR,9S,9aS,11R,11bR)-9-hydroxy-1-(methoxymethyl)-9a,11b-dimethyl-3,6-dioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
InChIKey: XLJORQYAOTYVQS-OGCOKEDGSA-N
SMILES: C[C@@]12C3=C(C(C4=C1C(C(O[C@@H]2COC)=O)=CO4)=O)[C@@]5([H])[C@](C[C@H]3OC(C)=O)([C@H](CC5)O)C
Biological Activity: 17β-Hydroxywortmannin (Wortmannin-17β-ol) is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM[1]. 17β-Hydroxywortmannin exhibits antitumor activity[2].
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17β-Hydroxywortmannin | 17β-Hydroxywortmannin (Wortmannin-17β-ol) is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM. 17β-Hydroxywortmannin exhibits antitumor activity. | |||||||||||||||||||||
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References
- [1]. Hall TJ, et al., Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro. Calcif Tissue Int. 1995 Apr;56(4):336-8. [Content Brief]
- [2]. Zask A, et al., Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51(5):1319-23. [Content Brief]
