58131-57-0
58131-57-0
Chemical Structure
NSC-207895
Synonym(s): XI-006
- CAS No.: 58131-57-0
- Formula:C11H13N5O4
- Molecular Weight:279.25
IUPAC Name: 7-(4-methylpiperazin-1-yl)-4-nitrobenzo[c][1,2,5]oxadiazole 1-oxide
InChIKey: MWFZDJLPWDCQIL-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=C(N2CCN(C)CC2)C3=[N+]([O-])ON=C31)[O-]
Biological Activity: NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator[1][2][3].
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NSC-207895 | 98.83% | NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator. | ||||||||||||||||||||
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References
- [1]. Laura Kapitzky, et al. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21;6:451. [Content Brief]
- [2]. Erdenezaya Odkhuu, et al. Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B. Immunobiology. 2015 Jan;220(1):136-41. [Content Brief]
- [3]. Luis A Carvajal, et al. Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med. 2018 Apr 11;10(436):eaao3003. [Content Brief]
