5845-67-0
5845-67-0
Chemical Structure
Cyclo(glycyl-L-leucyl)
Synonym(s): Cyclo(leu-gly)
- CAS No.: 5845-67-0
- Formula:C8H14N2O2
- Molecular Weight:170.21
IUPAC Name: (S)-3-isobutylpiperazine-2,5-dione
InChIKey: VQFHWKRNHGHZTK-LURJTMIESA-N
SMILES: CC(C[C@H]1C(NCC(N1)=O)=O)C
Biological Activity: Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cyclo(glycyl-L-leucyl) | 99.75% | Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias. | ||||||||||||||||||||
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References
- [1]. J Z Fields, et al. The effects of cyclo(leucyl-glycyl) on nigrostriatal dopaminergic supersensitivity--inhibition of apomorphine-induced climbing. Neuropeptides. 1990 Aug;16(4):207-11. [Content Brief]
- [2]. H N Bhargava, et al. Cyclo (leucylglycine) inhibits the development of morphine induced analgesic tolerance and dopamine receptor supersensitivity in rats. Life Sci. 1980 Jul 14;27(2):117-23. [Content Brief]
