5854-11-5
5854-11-5
Chemical Structure
CB 3705
- CAS No.: 5854-11-5
- Formula:C21H21N5O6
- Molecular Weight:439.42
IUPAC Name: (4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)amino)benzoyl)-L-glutamic acid
InChIKey: UQFCLENKCDVITL-INIZCTEOSA-N
SMILES: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CC3=C(NC(N)=NC3=O)C=C2)C=C1)=O
Biological Activity: CB 3705 is a dihydrofolate reductase (DHFR) and thymidylate synthetase (TS) inhibitor. CB 3705 inhibits L1210 cells and mutant L1210 cell line (L1210:C15) with ID50s of 4.77 μM and 408 μM, respectively[1][2].
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CB 3705 | CB 3705 is a dihydrofolate reductase (DHFR) and thymidylate synthetase (TS) inhibitor. CB 3705 inhibits L1210 cells and mutant L1210 cell line (L1210:C15) with ID50s of 4.77 μM and 408 μM, respectively. | |||||||||||||||||||||
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References
- [1]. Calvert AH, et al. Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance. Eur J Cancer (1965). 1980 May;16(5):713-22. [Content Brief]
- [2]. Jackman AL, et al. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies. Cancer Res. 1986 Jun;46(6):2810-5. [Content Brief]
