59032-40-5
59032-40-5
Chemical Structure
Disulergine
Synonym(s): CH 29-717
- CAS No.: 59032-40-5
- Formula:C17H24N4O2S
- Molecular Weight:348.46
InChIKey: VUEGYUOUAAVYAS-JGGQBBKZSA-N
SMILES: O=S(N[C@H](CN([C@@]1(CC2=CNC3=C2C4=CC=C3)[H])C)C[C@@]14[H])(N(C)C)=O
Biological Activity: Disulergine (CH 29-717) is an ergot alkaloid. Disulergine is a dopamine receptor agonist. Disulergine inhibits secretion of prolactin in rats. Disulergine inhibits growth hormone (GH) release[1][2][3].
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Disulergine | Disulergine (CH 29-717) is an ergot alkaloid. Disulergine is a dopamine receptor agonist. Disulergine inhibits secretion of prolactin in rats. Disulergine inhibits growth hormone (GH) release. | |||||||||||||||||||||
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References
- [1]. Spada A, et al. Differential transduction of dopamine signal in different subtypes of human growth hormone-secreting adenomas. J Clin Endocrinol Metab. 1994 Feb;78(2):411-7. [Content Brief]
- [2]. Markó M. Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines. Eur J Pharmacol. 1984 Jun 1;101(3-4):263-6. [Content Brief]
- [3]. Spada A, et al. In vitro effect of dopamine on growth hormone (GH) release from human GH-secreting pituitary adenomas. J Clin Endocrinol Metab. 1982 Oct;55(4):734-40. [Content Brief]
