5937-11-1
5937-11-1
Chemical Structure
T-Cadinol
- CAS No.: 5937-11-1
- Formula:C15H26O
- Molecular Weight:222.37
InChIKey: LHYHMMRYTDARSZ-XQLPTFJDSA-N
SMILES: CC([C@H]1[C@@]2([H])[C@](CCC(C)=C2)([H])[C@@](O)(CC1)C)C
Biological Activity: T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC50 values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease[1].
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T-Cadinol | 99.73% | T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC50 values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease. | ||||||||||||||||||||
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References
- [1]. Dos Santos AL, et al. (-)-T-Cadinol-a Sesquiterpene Isolated From Casearia sylvestris (Salicaceae)-Displayed In Vitro Activity and Causes Hyperpolarization of the Membrane Potential of Trypanosoma cruzi [published correction appears in Front Pharmacol. 2022 Mar 14;13:865432]. Front Pharmacol. 2021;12:734127. Published 2021 Nov 3. [Content Brief]
