5939-57-1
Chemical Structure
Cucurbitacin F
- CAS No.: 5939-57-1
- Formula:C30H46O7
- Molecular Weight:518.68
InChIKey: AOHIGMQGPFTKQX-QZPKXHNASA-N
SMILES: C[C@]12[C@@]([C@@]([C@@H](C1)O)([H])[C@@](C)(O)C(/C=C/C(C)(O)C)=O)(CC([C@@]3([C@@]2([H])CC=C4[C@@]3([H])C[C@@H]([C@H](C4(C)C)O)O)C)=O)C
Biological Activity: Cucurbitacin F is a tetracyclic protostane-type triterpenoid with low toxicity, antibacterial and anti-inflammatory activities, and is also a related compound of Cucurbitacin B (HY-N0416). Cucurbitacin F widely exists in plants such as Cucurbitaceae plants, Quisqualis indica and Sorbaria sorbifolia. Cucurbitacin F acts as an actin aggregator and reduces cell viability in a dose-dependent manner. Cucurbitacin F induces apoptosis by triggering G2/M phase cell cycle arrest and activating the caspase-3-dependent apoptosis[1][2][3][4][5].
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Cucurbitacin F | Cucurbitacin F is a tetracyclic protostane-type triterpenoid with low toxicity, antibacterial and anti-inflammatory activities, and is also a related compound of Cucurbitacin B (HY-N0416). Cucurbitacin F widely exists in plants such as Cucurbitaceae plants, Quisqualis indica and Sorbaria sorbifolia. Cucurbitacin F acts as an actin aggregator and reduces cell viability in a dose-dependent manner. Cucurbitacin F induces apoptosis by triggering G2/M phase cell cycle arrest and activating the caspase-3-dependent apoptosis. | |||||||||||||||||||||
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References
- [1]. Yin D, et al. Recent Advances in the Application of Cucurbitacin B as an Anticancer Agent. Int J Mol Sci. 2025;26(16):8003. Published 2025 Aug 19. [Content Brief]
- [2]. Lohberger B, et al. 25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells. J Ethnopharmacol. 2015;164:265-272. [Content Brief]
- [3]. Sörensen PM, et al. The natural product cucurbitacin E inhibits depolymerization of actin filaments. ACS Chem Biol. 2012;7(9):1502-1508. [Content Brief]
- [4]. Lee S M, et al. Toxic evaluation and chromatographic analysis of cucurbitacin D and F from Sorbaria sorbifolia[J]. Analytical Science and Technology, 2001, 14(2): 191-195.
- [5]. Yang P, et al. Separation of Cucurbitacins by Overpressure Layer Chromatography from Hemsleya gigantha1. Planta Med. 1988 Aug;54(4):349-51. [Content Brief]
