59587-50-7
Chemical Structure
N6-(2-Aminoethyl)-NAD+
Synonym(s): 6-AE-NAD+
- CAS No.: 59587-50-7
- Formula:C23H32N8O14P2
- Molecular Weight:706.49
IUPAC Name: 1-((2R,3R,4S,5R)-5-((((((((2R,3S,4R,5R)-5-(6-((2-aminoethyl)amino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-3-carbamoylpyridin-1-ium
InChIKey: QDIRJGBLIZPDDJ-BSLNIGMPSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](COP(OP(OC[C@H]2O[C@@H]([N+]3=CC=CC(C(N)=O)=C3)[C@H](O)[C@@H]2O)([O-])=O)(O)=O)O[C@H]1N(C=N4)C5=C4C(NCCN)=NC=N5
Biological Activity: N6-(2-Aminoethyl)-NAD+ (6-AE-NAD+) is an adenine-modified NAD analog with coenzyme activity and the property of targeting lactate dehydrogenase (LDH). N6-(2-Aminoethyl)-NAD+ undergoes transient affinity binding with LDH, thereby crosslinking the enzyme monolayer into an integrated electrode. N6-(2-Aminoethyl)-NAD+ is a component of the PQQ (HY-100196)-NAD+ binary interface, and supports the bioelectrocatalytic oxidation of lactate through PQQ-mediated immobilized NADH oxidation[1][2].
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N6-(2-Aminoethyl)-NAD+ | N6-(2-Aminoethyl)-NAD+ (6-AE-NAD+) is an adenine-modified NAD analog with coenzyme activity and the property of targeting lactate dehydrogenase (LDH). N6-(2-Aminoethyl)-NAD+ undergoes transient affinity binding with LDH, thereby crosslinking the enzyme monolayer into an integrated electrode. N6-(2-Aminoethyl)-NAD+ is a component of the PQQ (HY-100196)-NAD+ binary interface, and supports the bioelectrocatalytic oxidation of lactate through PQQ-mediated immobilized NADH oxidation. | |||||||||||||||||||||
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References
- [1]. Katz E, et al. Fully integrated biocatalytic electrodes based on bioaffinity interactions. Biosens Bioelectron. 1998 Oct 1;13(7-8):741-56. [Content Brief]
- [2]. Hendle J, et al. Structure/activity relationship of adenine-modified NAD derivatives with respect to porcine heart lactate dehydrogenase isozyme H4 simulated with molecular mechanics. European journal of biochemistry. 1993 May 01;213(3):947-56. [Content Brief]
