5977-35-5
5977-35-5
Chemical Structure
IOB-82
Synonym(s): NSC-146171
- CAS No.: 5977-35-5
- Formula:C12H15Cl2NO2
- Molecular Weight:276.16
InChIKey: DKROWFJGHDLNFQ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C)C(N(CCCl)CCCl)=C1)O
Biological Activity: IOB-82 is a bifunctional alkylating agent. IOB‑82 induces marked nuclear and cytoplasmic alterations, elicits severe chromatid and chromosome aberrations, and remodels chromosome ploidy. IOB-82 exerts dose-dependent radiomimetic effects and preferentially cytotoxic to large A-type rat ascites cells. IOB-82 can be applied in the research of melanoma‑derived tumors and leukemia[1][2].
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IOB-82 | IOB-82 is a bifunctional alkylating agent. IOB‑82 induces marked nuclear and cytoplasmic alterations, elicits severe chromatid and chromosome aberrations, and remodels chromosome ploidy. IOB-82 exerts dose-dependent radiomimetic effects and preferentially cytotoxic to large A-type rat ascites cells. IOB-82 can be applied in the research of melanoma‑derived tumors and leukemia. | |||||||||||||||||||||
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References
- [1]. Kapou A, et al. 3D QSAR/CoMFA and CoMSIA studies on antileukemic steroidal esters coupled with conformationally flexible nitrogen mustards. J Chem Inf Model. 2008;48(11):2254-2264. [Content Brief]
- [2]. Dumitrescu L, et al. Morphological and cytogenetical changes in HR-18 rat ascites cells after in vitro 3-[bis(2-chloroethyl)amino]-4-methylbenzoic acid (NSC-146171; IOB-82) administration. Tumori. 1978;64(4):361-370. [Content Brief]
