60084-10-8
Chemical Structure
Tiazofurin
Synonym(s): NSC 286193; Riboxamide
- CAS No.: 60084-10-8
- Formula:C9H12N2O5S
- Molecular Weight:260.27
IUPAC Name: 2-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)thiazole-4-carboxamide
InChIKey: FVRDYQYEVDDKCR-DBRKOABJSA-N
SMILES: O=C(N)C1=CSC([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=N1
Biological Activity: Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin enhances the autosecretion of IL-6 in K562 cells. Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin can be used for the study of leukemia and lung cancer[1][2][3][4].
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Tiazofurin | 99.82% | Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin enhances the autosecretion of IL-6 in K562 cells. Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin can be used for the study of leukemia and lung cancer. | ||||||||||||||||||||
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References
- [1]. Talley CJ, et al. Tiazofurin-induced autosecretion of IL-6 and hemoglobin production in K562 human leukemia cells. Am J Hematol. 1997 Apr;54(4):301-5. [Content Brief]
- [2]. Ahluwalia GS, et al. Studies on the mechanism of action of 2-beta-D-ribofuranosylthiazole-4-carboxamide--V. Factors governing the response of murine tumors to tiazofurin. Biochem Pharmacol. 1984 Apr 15;33(8):1195-203. [Content Brief]
- [3]. Tricot G, Jayaram HN, Weber G, Hoffman R. Tiazofurin: biological effects and clinical uses. Int J Cell Cloning. 1990;8(3):161-170. [Content Brief]
- [4]. Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23. [Content Brief]
