603101-22-0
603101-22-0
Chemical Structure
GNF-1331
- CAS No.: 603101-22-0
- Formula:C20H20N6O2S2
- Molecular Weight:440.54
IUPAC Name: N-(6-methoxybenzo[d]thiazol-2-yl)-2-((4-propyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide
InChIKey: JIUFLMSAFMXEEC-UHFFFAOYSA-N
SMILES: O=C(CSC1=NN=C(N1CCC)C2=CC=NC=C2)NC3=NC4=CC=C(C=C4S3)OC
Biological Activity: GNF-1331 (compound 19) is a potent, selective and orally bioavailable porcupine inhibitor (IC50=12 nM). GNF-1331 blocks Wnt ligand secretion and subsequent Wnt signaling activity, and induces significant antitumor effects in the mouse MMTV-WNT1 xenograft tumor model[1].
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GNF-1331 | 99.84% | GNF-1331 (compound 19) is a potent, selective and orally bioavailable porcupine inhibitor (IC50=12 nM). GNF-1331 blocks Wnt ligand secretion and subsequent Wnt signaling activity, and induces significant antitumor effects in the mouse MMTV-WNT1 xenograft tumor model. | ||||||||||||||||||||
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