60576-13-8
60576-13-8
Chemical Structure
Piketoprofen
- CAS No.: 60576-13-8
- Formula:C22H20N2O2
- Molecular Weight:344.41
IUPAC Name: 2-(3-benzoylphenyl)-N-(4-methylpyridin-2-yl)propanamide
InChIKey: ASFKKFRSMGBFRO-UHFFFAOYSA-N
SMILES: O=C(NC1=NC=CC(C)=C1)C(C)C2=CC=CC(C(C3=CC=CC=C3)=O)=C2
Biological Activity: Piketoprofen is a non-steroidal anti-inflammatory reagent that can be used as a cream preparation for the study of soft tissue rheumatism. Piketoprofen-amide is a prodrug of COX-2 inhibitor[1][2].
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Piketoprofen | 99.54% | Piketoprofen is a non-steroidal anti-inflammatory reagent that can be used as a cream preparation for the study of soft tissue rheumatism. Piketoprofen-amide is a prodrug of COX-2 inhibitor. | ||||||||||||||||||||
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Piketoprofen (Standard) | ≥98% | Piketoprofen (Standard) is the analytical standard of Piketoprofen. This product is intended for research and analytical applications. Piketoprofen is a non-steroidal anti-inflammatory reagent that can be used as a cream preparation for the study of soft tissue rheumatism. | ||||||||||||||||||||
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Ketoprofen impurity 11 | Ketoprofen impurity 11 is an impurity of Ketoprofen. | |||||||||||||||||||||
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RIOK2-IN-1 | RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression. | |||||||||||||||||||||
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Ketoprofen sodium | Ketoprofen (RP-19583) sodium is a non-steroidal anti-inflammatory agent. Ketoprofen sodium can inhibit the activity of Cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). Ketoprofen is potential in the research of inflammation, immunology, and metabolic disease such as obesity. | |||||||||||||||||||||
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Ketoprofen | 99.95% | Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity. | ||||||||||||||||||||
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Ketoprofen-13C6 | Ketoprofen-13C6 (RP-19583-13C6) is 13C labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity. | |||||||||||||||||||||
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S-(+)-Ketoprofen (Standard) | ≥98% | S-(+)-Ketoprofen (Standard) is the analytical standard of S-(+)-Ketoprofen. This product is intended for research and analytical applications. S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively. | ||||||||||||||||||||
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(R)-Ketoprofen | 95.0% | (R)-Ketoprofen is an orally active nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties. (R)-Ketoprofen does not significantly amplify the increase of inflammatory cytokines (such as tumor necrosis factor (TNF) and interleukin-1 (IL-1)) induced by LPS, but it can inhibit the anti-inflammatory activity of (S)-Ketoprofen. | ||||||||||||||||||||
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Ketoprofen impurity 10 | Ketoprofen impurity 10 is an impurity of Ketoprofen. | |||||||||||||||||||||
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Ketoprofen impurity 4 | Ketoprofen impurity 4 (rac-4’-Methyl ketoprofen) is an impurity of Ketoprofen. | |||||||||||||||||||||
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Ketoprofen impurity 5 | Ketoprofen impurity 5 (rac Ketoprofen amide) is an impurity of Ketoprofen. | |||||||||||||||||||||
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References
- [1]. Chen W, et al. New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases. Mol Med. 2021 Sep 30;27(1):123. [Content Brief]
- [2]. Burgos A, et al. Double-blind, double-dummy comparative study of local action transcutaneous flurbiprofen (flurbiprofen LAT) versus piketoprofen cream in the treatment of extra-articular rheumatism[J]. Clinical Drug Investigation, 2001, 21: 95-102.
