60719-83-7
60719-83-7
Chemical Structure
Alaproclate hydrochloride
Synonym(s): GEA 654 hydrochloride; A03 hydrochloride
- CAS No.: 60719-83-7
- Formula:C13H19Cl2NO2
- Molecular Weight:292.20
IUPAC Name: 1-(4-chlorophenyl)-2-methylpropan-2-yl alaninate hydrochloride
InChIKey: OPAKSOWFKIUFNP-UHFFFAOYSA-N
SMILES: NC(C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O.[H]Cl
Biological Activity: Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow[1][2].
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Alaproclate hydrochloride | Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow. | |||||||||||||||||||||
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References
- [1]. Campagna J, et al. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 Dec 4;8(1):17574. [Content Brief]
- [2]. Wilkinson A, et al. Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow. [Content Brief]
