6093-68-1
Chemical Structure
6-Hydroxycoumarin
- CAS No.: 6093-68-1
- Formula:C9H6O3
- Molecular Weight:162.14
IUPAC Name: 6-hydroxy-2H-chromen-2-one
InChIKey: CJIJXIFQYOPWTF-UHFFFAOYSA-N
SMILES: O=C1C=CC2=CC(O)=CC=C2O1
Biological Activity: 6-Hydroxycoumarin is a plant-derived secondary metabolite of the coumarin class, possessing insecticidal, antitumor, and other biological activities. 6-Hydroxycoumarin targets the midgut tissue of the red imported fire ant (Solenopsis invicta), inhibits CYP450, induces elevated activities of GST, CarE, and SOD, disrupts mitochondrial ultrastructure, triggers apoptosis, and also impairs insect neuromuscular behavior. 6-Hydroxycoumarin exhibits photoallergic properties and serves as an intermediate for the synthesis of isoxazolyl and triazolyl derivatives. 6-Hydroxycoumarin is applicable to research related to red imported fire ant control[1][2][3].
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6-Hydroxycoumarin | 99.32% | 6-Hydroxycoumarin is a plant-derived secondary metabolite of the coumarin class, possessing insecticidal, antitumor, and other biological activities. 6-Hydroxycoumarin targets the midgut tissue of the red imported fire ant (Solenopsis invicta), inhibits CYP450, induces elevated activities of GST, CarE, and SOD, disrupts mitochondrial ultrastructure, triggers apoptosis, and also impairs insect neuromuscular behavior. 6-Hydroxycoumarin exhibits photoallergic properties and serves as an intermediate for the synthesis of isoxazolyl and triazolyl derivatives. 6-Hydroxycoumarin is applicable to research related to red imported fire ant control. | ||||||||||||||||||||
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6-Hydroxycoumarin (Standard) | ≥98% | 6-Hydroxycoumarin (Standard) is the analytical standard of 6-Hydroxycoumarin (HY-N6656). This product is intended for research and analytical applications. 6-Hydroxycoumarin is a plant-derived secondary metabolite of the coumarin class, possessing insecticidal, antitumor, and other biological activities. 6-Hydroxycoumarin targets the midgut tissue of the red imported fire ant (Solenopsis invicta), inhibits CYP450, induces elevated activities of GST, CarE, and SOD, disrupts mitochondrial ultrastructure, triggers apoptosis, and also impairs insect neuromuscular behavior. 6-Hydroxycoumarin exhibits photoallergic properties and serves as an intermediate for the synthesis of isoxazolyl and triazolyl derivatives. 6-Hydroxycoumarin is applicable to research related to red imported fire ant control. | ||||||||||||||||||||
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References
- [1]. Luo R, et al. 6-Hydroxycoumarin from Artemisia lavandulaefolia Induces Multimodal Toxicity in Solenopsis invicta via behavioral inhibition and mitochondrial disruption. Ecotoxicology and environmental safety. 2026 Jun 15;318:120209. [Content Brief]
- [2]. Egan D. The Pharmacology, Metabolism, Analysis, and Applications of Coumarin and Coumarin-Related Compounds. Drug Metabolism Reviews, 2008, 22(5): 503-529.
- [3]. Shakeel-u-Rehman, et al. Synthesis and biological evaluation of novel isoxazoles and triazoles linked 6-hydroxycoumarin as potent cytotoxic agents. Bioorganic & medicinal chemistry letters. 2014 Sep 01;24(17):4243-6. [Content Brief]
