612542-14-0
612542-14-0
Chemical Structure
Hh-Ag1.5
Synonym(s): SAg1.5
- CAS No.: 612542-14-0
- Formula:C28H26ClF2N3OS
- Molecular Weight:526.04
IUPAC Name: 3-chloro-4,7-difluoro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide
InChIKey: RXZDWPYJFCAZCW-MEMLXQNLSA-N
SMILES: O=C(C(SC1=C(C=C2)F)=C(C1=C2F)Cl)N([C@@H](CC3)CC[C@H]3NC)CC4=CC(C5=CC=NC=C5)=CC=C4
Biological Activity: Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM[1]. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hh-Ag1.5 | 99.90% | Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure. | ||||||||||||||||||||
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References
- [1]. Randall W King. Roughing Up Smoothened: Chemical Modulators of Hedgehog Signaling. J Biol. 2002 Nov 6;1(2):8. [Content Brief]
- [2]. Abhisek Mitra, et al. A Small Molecule Hedgehog Agonist HhAg1.5 Mediated Reprogramming Breaks the Quiescence of Noninjured Liver Stem Cells for Rescuing Liver Failure. Transl Res. 2019 Mar;205:44-50. [Content Brief]
