61419-02-1
Chemical Structure
Naphthofluorescein
Synonym(s): Naphthafluorescein
- CAS No.: 61419-02-1
- Formula:C28H16O5
- Molecular Weight:432.42
IUPAC Name: 3,11-dihydroxy-3'H-spiro[dibenzo[c,h]xanthene-7,1'-isobenzofuran]-3'-one
InChIKey: IXQIUDNVFVTQLJ-UHFFFAOYSA-N
SMILES: O=C(C1=C2C=CC=C1)OC32C4=C(OC5=C3C=CC6=CC(O)=CC=C56)C7=CC=C(O)C=C7C=C4
Biological Activity: Naphthofluorescein inhibits the interaction between HIF-1 and Mint3. Naphthofluorescein suppresses Mint3-dependent HIF-1 activity and glycolysis in cancer cells and macrophages without cytotoxicity in vitro and adverse effect in vivo[1]. Naphthofluorescein is also a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Naphthofluorescein | 99.02% | Naphthofluorescein inhibits the interaction between HIF-1 and Mint3. Naphthofluorescein suppresses Mint3-dependent HIF-1 activity and glycolysis in cancer cells and macrophages without cytotoxicity in vitro and adverse effect in vivo. Naphthofluorescein is also a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging. | ||||||||||||||||||||
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References
- [1]. Sakamoto T, et al. Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock. Commun Biol. 2021;4(1):1165. Published 2021 Oct 7. [Content Brief]
- [2]. Arroyo AD, et al. Development of fluorinated naphthofluoresceins for Cerenkov imaging. J Fluor Chem. 2019;225:27-34. [Content Brief]
