62145-07-7
Chemical Structure
11-keto Fluprostenol
Synonym(s): Fluprostenol Prostaglandin D2
- CAS No.: 62145-07-7
- Formula:C23H27F3O6
- Molecular Weight:456.45
IUPAC Name: (Z)-7-((1R,2R,5S)-5-hydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-3-oxocyclopentyl)hept-5-enoic acid
InChIKey: MDMHJAKZGBRYTF-KYUUVOLFSA-N
SMILES: O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2)C(C[C@@H]1O)=O
Biological Activity: 11-keto Fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.
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11-keto Fluprostenol | 11-keto Fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor. | |||||||||||||||||||||
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