62346-20-7
62346-20-7
Chemical Structure
Buddledin A
- CAS No.: 62346-20-7
- Formula:C17H24O3
- Molecular Weight:276.37
InChIKey: SXWKLEULMBLXJM-PCRFWOPQSA-N
SMILES: O=C(/C(C)=C/CC1)[C@H](OC(C)=O)[C@@]2([H])C(C)(C)C[C@]2([H])C1=C
Biological Activity: Buddledin A is a 5-LOX inhibitor (IC50 = 50.4 μM) and a COX inhibitor (IC50 = 13.7 μM). Buddedin A inhibits arachidonic acid metabolism via the 5-LOX and COX pathways, suppresses fungal growth, and exerts toxic effects on fish. Buddedin A may play an ecological role in protecting plant roots and stem barks from fungal infection. Buddedin A can be used in studies related to fungal infections[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Buddledin A | Buddledin A is a 5-LOX inhibitor (IC50 = 50.4 μM) and a COX inhibitor (IC50 = 13.7 μM). Buddedin A inhibits arachidonic acid metabolism via the 5-LOX and COX pathways, suppresses fungal growth, and exerts toxic effects on fish. Buddedin A may play an ecological role in protecting plant roots and stem barks from fungal infection. Buddedin A can be used in studies related to fungal infections. | |||||||||||||||||||||
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References
- [1]. Liao YH, et al. Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation. J Nat Prod. 1999;62(9):1241-1245. [Content Brief]
- [2]. Houghton PJ, et al. Terpenoids in Buddleja: relevance to chemosystematics, chemical ecology and biological activity. Phytochemistry. 2003;64(2):385-393. [Content Brief]
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[3]. Takashi Yoshida, et al. Buddledin A, B and C, piscicidal sesquiterpenes from Buddleja davidi[CITATION]Franch. Tetrahedron Letters No. 41, pp 3717-3720, 1976. Pergamon Press.
Printed in Great Britain.
