62462-98-0
Chemical Structure
Linichlorin A
- CAS No.: 62462-98-0
- Formula:C19H23ClO6
- Molecular Weight:382.84
IUPAC Name: (3aR,4S,6aR,8S,9S,9aS,9bS)-9-(chloromethyl)-8,9-dihydroxy-3,6-dimethylene-2-oxododecahydroazuleno[4,5-b]furan-4-yl methacrylate
InChIKey: ONMAQPPVCANFPB-URUZQALBSA-N
SMILES: C(Cl)[C@]1(O)[C@@]2([C@@]3([C@@]([C@@H](OC(C(C)=C)=O)CC(=C)[C@@]2(C[C@@H]1O)[H])(C(=C)C(=O)O3)[H])[H])[H]
Biological Activity: Linichlorin A is a p27Kip1 ubiquitination inhibitor that blocks p27Kip1 degradation by inhibiting the Skp2-Cks1–p27Kip1 interaction. Linichlorin A shows selective antiproliferative activity against tumor cells. Linichlorin A induces apoptosis in leukemia cells via cytochrome c release, caspase activation and PARP cleavage. Linichlorin A can be used in the study of leukemia, melanoma, cervical cancer and breast cancer[1][2].
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Linichlorin A | Linichlorin A is a p27Kip1 ubiquitination inhibitor that blocks p27Kip1 degradation by inhibiting the Skp2-Cks1–p27Kip1 interaction. Linichlorin A shows selective antiproliferative activity against tumor cells. Linichlorin A induces apoptosis in leukemia cells via cytochrome c release, caspase activation and PARP cleavage. Linichlorin A can be used in the study of leukemia, melanoma, cervical cancer and breast cancer. | |||||||||||||||||||||
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References
- [1]. Estévez-Sarmiento F, et al. Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells. Int J Mol Sci. 2020 Dec 21;21(24):9767. [Content Brief]
- [2]. Ooi LC, et al. Identification of small molecule inhibitors of p27(Kip1) ubiquitination by high-throughput screening. Cancer Sci. 2013 Nov;104(11):1461-7. [Content Brief]
