627525-33-1
627525-33-1
Chemical Structure
EVT-101 free base
Synonym(s): ENS-101 free base
- CAS No.: 627525-33-1
- Formula:C16H13F3N4
- Molecular Weight:318.30
IUPAC Name: 5-(3-(difluoromethyl)-4-fluorophenyl)-3-((2-methyl-1H-imidazol-1-yl)methyl)pyridazine
InChIKey: BOVUHBFXPNLTKF-UHFFFAOYSA-N
SMILES: CC1=NC=CN1CC2=NN=CC(C3=CC=C(F)C(C(F)F)=C3)=C2
Biological Activity: EVT-101 free base is a GluN2B antagonist. EVT-101 free base binds at the same GluN1/GluN2B dimer interface as Ifenprodil (HY-12882). EVT-101 free base inhibits calcium influx in chicken-derived cells, with an EC50 of 22 nM. EVT-101 can be used in the research of brain disorders[1][2].
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EVT-101 free base | EVT-101 free base is a GluN2B antagonist. EVT-101 free base binds at the same GluN1/GluN2B dimer interface as Ifenprodil (HY-12882). EVT-101 free base inhibits calcium influx in chicken-derived cells, with an EC50 of 22 nM. EVT-101 can be used in the research of brain disorders. | |||||||||||||||||||||
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References
- [1]. Stroebel D, et al. A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists. Mol Pharmacol. 2016 May;89(5):541-51. [Content Brief]
- [2]. Fjelldal MF, et al. Exploring the overlapping binding sites of ifenprodil and EVT-101 in GluN2B-containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling. Pharmacol Res Perspect. 2019 May 30;7(3):e00480. [Content Brief]
