630-19-3
Chemical Structure
Trimethylacetaldehyde
Synonym(s): Pivalic aldehyde; Pivalaldehyde
- CAS No.: 630-19-3
- Formula:C5H10O
- Molecular Weight:86.13
IUPAC Name: pivalaldehyde
InChIKey: FJJYHTVHBVXEEQ-UHFFFAOYSA-N
SMILES: O=CC(C)(C)C
Biological Activity: Trimethylacetaldehyde (Pivalic aldehyde; Pivalaldehyde) is an inhibitor of E. coli betaine aldehyde dehydrogenase (ALDH) with a Ki of 4.5 mM. Trimethylacetaldehyde serves as a substrate for Drosophila melanogaster alcohol dehydrogenase (AdhS), undergoing oxidation and disproportionation reactions with the release of NADH, and also forms an inactive binary enzyme-aldehyde complex via a compulsory ordered reaction mechanism[1][2].
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Trimethylacetaldehyde | Trimethylacetaldehyde (Pivalic aldehyde; Pivalaldehyde) is an inhibitor of E. coli betaine aldehyde dehydrogenase (ALDH) with a Ki of 4.5 mM. Trimethylacetaldehyde serves as a substrate for Drosophila melanogaster alcohol dehydrogenase (AdhS), undergoing oxidation and disproportionation reactions with the release of NADH, and also forms an inactive binary enzyme-aldehyde complex via a compulsory ordered reaction mechanism. | |||||||||||||||||||||
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References
- [1]. Winberg JO, et al. Drosophila melanogaster alcohol dehydrogenase: mechanism of aldehyde oxidation and dismutation. The Biochemical journal. 1998 Feb 01;329 ( Pt 3)(Pt 3):561-70. [Content Brief]
- [2]. Falkenberg P, et al. Purification and characterization of osmoregulatory betaine aldehyde dehydrogenase of Escherichia coli. Biochimica et biophysica acta. 1990 Jun 20;1034(3):253-9. [Content Brief]
