630407-66-8
630407-66-8
Chemical Structure
SB-773812
- CAS No.: 630407-66-8
- Formula:C25H26ClNO4S
- Molecular Weight:472.00
IUPAC Name: 7-((4-((4-chlorobenzyl)oxy)phenyl)sulfonyl)-8-methoxy-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
InChIKey: HIBWHHQXUSKNOV-UHFFFAOYSA-N
SMILES: CN1CCC2=CC(OC)=C(S(=O)(C3=CC=C(OCC4=CC=C(Cl)C=C4)C=C3)=O)C=C2CC1
Biological Activity: SB-773812 is a moderate-affinity antagonist at dopamine receptor 2 (pKi=7.4) and a high-affinity antagonist at the dopamine receptor 3 (pKi=8.5) and at the serotonin 5-hydroxytryptamine receptors 2A (pKi=9.0), 2C (pKi=8.1), and 6 (pKi=8.1). SB-773812 is promising for research of central nervous system disorders[1][2].
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SB-773812 | SB-773812 is a moderate-affinity antagonist at dopamine receptor 2 (pKi=7.4) and a high-affinity antagonist at the dopamine receptor 3 (pKi=8.5) and at the serotonin 5-hydroxytryptamine receptors 2A (pKi=9.0), 2C (pKi=8.1), and 6 (pKi=8.1). SB-773812 is promising for research of central nervous system disorders. | |||||||||||||||||||||
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References
- [1]. Garg A, et al. Amit Garg A Mechanism Based Population Pharmacokinetic-Pharmacodynamic Model for Epoetin Alfa and Darbepoetin Alfa in Chronic Kidney Disease Patients[J]. Poster Abstracts PAGE 2010, 47.
- [2]. Catafau AM, et al. Contribution of SPECT measurements of D2 and 5-HT2A occupancy to the clinical development of the antipsychotic SB-773812. J Nucl Med. 2011 Apr;52(4):526-34. [Content Brief]
