634193-54-7
634193-54-7
Chemical Structure
L-902688
- CAS No.: 634193-54-7
- Formula:C21H27F2N5O2
- Molecular Weight:419.47
IUPAC Name: (R)-1-(6-(1H-tetrazol-5-yl)hexyl)-5-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)pyrrolidin-2-one
InChIKey: WPTLQOYLIXWRNN-SLKVGHROSA-N
SMILES: O[C@@]([H])(C(F)(C1=CC=CC=C1)F)/C=C/[C@@H](CCC2=O)N2CCCCCCC3=NN=NN3
Biological Activity: L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors[1][2].
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L-902688 | 99.0% | L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors. | ||||||||||||||||||||
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References
- [1]. Lai YJ, et al. EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension. Int J Mol Sci. 2018 Mar 3;19(3). pii: E727. [Content Brief]
- [2]. [2]Young, R.N., Billot, X., Han, Y., et al. Discovery and synthesis of a potent, selective and orally bioavailable EP4 receptor agonist. Heterocycles. 2004, 64, 437-445.
