634908-46-6
Chemical Structure
SCFSkp2-IN-1 dihydrochloride
- CAS No.: 634908-46-6
- Formula:C26H40Cl2N2O
- Molecular Weight:467.51
IUPAC Name: 4-(((3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-phenylbutyl)amino)methyl)-N,N-dimethylaniline hydrochloride
InChIKey: WOGGLGQSKKLANW-UHFFFAOYSA-N
SMILES: CC1(C)CC(C(CCNCC2=CC=C(N(C)C)C=C2)CC3=CC=CC=C3)CCO1.Cl.Cl
Biological Activity: SCFSkp2-IN-1 dihydrochloride is a SCFSkp2 E3 ligase inhibitor. SCFSkp2-IN-1 dihydrochloride prevents Skp2 incorporation into the SCFSkp2 complex by disrupting Skp1-Skp2 binding, inhibits p27 ubiquitination, and stabilizes p27, p21, and p57. SCFSkp2-IN-1 dihydrochloride induces autophagy and cell cycle arrest. SCFSkp2-IN-1 dihydrochloride overcomes drug resistance in multiple myeloma models and exhibits synergistic antitumor effects with Bortezomib (HY-10227). SCFSkp2-IN-1 dihydrochloride can be used for research related to multiple myeloma and leukemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SCFSkp2-IN-1 dihydrochloride | SCFSkp2-IN-1 dihydrochloride is a SCFSkp2 E3 ligase inhibitor. SCFSkp2-IN-1 dihydrochloride prevents Skp2 incorporation into the SCFSkp2 complex by disrupting Skp1-Skp2 binding, inhibits p27 ubiquitination, and stabilizes p27, p21, and p57. SCFSkp2-IN-1 dihydrochloride induces autophagy and cell cycle arrest. SCFSkp2-IN-1 dihydrochloride overcomes drug resistance in multiple myeloma models and exhibits synergistic antitumor effects with Bortezomib (HY-10227). SCFSkp2-IN-1 dihydrochloride can be used for research related to multiple myeloma and leukemia. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
